Abdominal aortic aneurysm

Acanthosis nigricans

Achalasia

Acid and chemical burns

Acid reflux in babies, see Reflux in babies

Acid reflux, see Heartburn and acid reflux

Acne

Acoustic neuroma (vestibular schwannoma)

Acromegaly

Actinic keratoses (solar keratoses)

Actinomycosis

Acute cholecystitis

Acute kidney injury (AKI)

Acute lymphoblastic leukaemia

Acute myeloid leukaemia

Acute pancreatitis

Acute respiratory distress syndrome (ARDS)

Addison’s disease

Adenomyosis

ADHD in adults

ADHD in children and young people

Age-related macular degeneration (AMD)

Agoraphobia

AKI, see Acute kidney injury (AKI)

Albinism

Alcohol poisoning

Alcohol-related liver disease

Alcohol-use disorder

Allergic rhinitis

Allergies

Altitude sickness

Alzheimer’s disease

Amblyopia, see Lazy eye

Amyloidosis

Anabolic steroid misuse

Anaemia (iron deficiency), see Iron deficiency anaemia

Anaemia (vitamin B12 or folate deficiency), see Vitamin B12 or folate deficiency anaemia

Anal cancer

Anal fissure

Anal fistula

Anaphylaxis

Androgen insensitivity syndrome

Aneurysm (abdominal aortic), see Abdominal aortic aneurysm

Aneurysm (brain), see Brain aneurysm

Angelman syndrome

Angina

Angioedema

Animal and human bites

Ankles (swollen), see Swollen ankles, feet and legs (oedema)

Ankylosing spondylitis

Anorexia nervosa

Antiphospholipid syndrome (APS)

Anxiety disorders in children

Anxiety in pregnancy

Aphasia

Appendicitis

Arrhythmia, see Heart rhythm problems (arrhythmia)

Arthritis

Asbestosis

Aspergillosis

Asthma

Astigmatism

Ataxia

Atherosclerosis

Athlete’s foot

Atopic eczema

Atrial fibrillation

Auditory processing disorder (APD)

Autism

Autosomal dominant polycystic kidney disease

Autosomal recessive polycystic kidney disease

Avian flu, see Bird flu

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B

Back pain

Bacterial vaginosis

Baker’s cyst

Balanitis

Bartholin’s cyst

Bedbugs

Behçet’s disease

Bell’s palsy

Benign brain tumours, see Non-cancerous (benign) brain tumours

Benign prostate enlargement, see Enlarged prostate

Bile duct cancer (cholangiocarcinoma)

Bilharzia, see Schistosomiasis (bilharzia)

Binge eating disorder

Bipolar disorder

Bird flu

Birthmarks

Bite (animal or human), see Animal and human bites

Black eye

Bladder cancer

Bladder pain syndrome (BPS)

Bladder stones

Blepharitis

Blisters

Blood pressure (high), see High blood pressure

Blood pressure (low), see Low blood pressure (hypotension)

Body dysmorphic disorder (BDD)

Boils

Bone cancer

Bone cyst

Borderline personality disorder

Botulism

Bowel cancer

Bowel incontinence

Bowel polyps

Bowen’s disease

Brachycephaly and plagiocephaly, see Flat head syndrome (plagiocephaly and brachycephaly)

Brain abscess

Brain aneurysm

Brain death

Brain haemorrhage, see Subarachnoid haemorrhage

Brain tumours

Brain tumours (benign), see Non-cancerous (benign) brain tumours

Breast abscess

Breast cancer in men

Breast cancer in women

Breath-holding in babies and children

Broken ankle

Broken arm or wrist

Broken collarbone

Broken finger or thumb

Broken hip

Broken leg

Broken nose

Broken or bruised ribs

Broken toe

Bronchiectasis

Bronchiolitis

Bronchitis

Brucellosis

Brugada syndrome

Bulimia

Bullous pemphigoid

Bunions

Burns and scalds

Bursitis

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C

Cancer

Carbon monoxide poisoning

Cardiomyopathy

Cardiovascular disease

Carpal tunnel syndrome

Cat bites, see Animal and human bites

Cataracts (children), see Childhood cataracts

Cataracts in adults

Catarrh

Cavernoma

Cellulitis

Cerebral palsy

Cervical cancer

Cervical spondylosis

Charcot-Marie-Tooth disease

Charles Bonnet syndrome

Chest infection

Chiari malformation

Chickenpox

Chilblains

Childhood cataracts

Chipped, broken or cracked tooth

Chlamydia

Cholecystitis (acute), see Acute cholecystitis

Cholera

Cholesteatoma

Cholesterol (high), see High cholesterol

Chronic fatigue syndrome (ME/CFS), see Myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS)

Chronic kidney disease

Chronic lymphocytic leukaemia

Chronic myeloid leukaemia

Chronic obstructive pulmonary disease (COPD)

Chronic pancreatitis

Chronic traumatic encephalopathy

Cirrhosis

CJD, see Creutzfeldt-Jakob disease

Claustrophobia

Cleft lip and palate

Clostridioides difficile (C. diff) infection

Clubfoot

Cluster headaches

Coccyx pain, see Tailbone (coccyx) pain

Coeliac disease

Cold sores

Colic

Colon cancer, see Bowel cancer

Colour vision deficiency (colour blindness)

Common cold

Compartment syndrome

Complex regional pain syndrome

Concussion, see Head injury and concussion

Congenital heart disease

Congenital hip dislocation, see Developmental dysplasia of the hip

Conjunctivitis

Constipation

Contact dermatitis

Corns and calluses

Coronary heart disease

Coronavirus, see COVID-19

Corticobasal degeneration

Costochondritis

COVID-19

Cradle cap

Craniosynostosis

Creutzfeldt-Jakob disease

Crohn’s disease

Croup

Cushing’s syndrome

Cuts and grazes

Cyclical vomiting syndrome

Cyclospora

Cyclothymia

Cystic fibrosis

Cystitis, see Urinary tract infections (UTIs)

Cytomegalovirus (CMV)

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D

Dandruff

Deafness, see Hearing loss

Dehydration

Dementia

Dementia (frontotemporal), see Frontotemporal dementia

Dementia (vascular), see Vascular dementia

Dementia with Lewy bodies

Dengue

Dental abscess

Depression

Depression in adults

Detached retina (retinal detachment)

Developmental co-ordination disorder (dyspraxia) in adults, see Dyspraxia in adults

Developmental co-ordination disorder (dyspraxia) in children

Developmental dysplasia of the hip

Diabetes

Diabetes (type 1), see Type 1 diabetes

Diabetes (type 2), see Type 2 diabetes

Diabetes in pregnancy, see Gestational diabetes

Diabetes insipidus

Diabetic ketoacidosis

Diabetic retinopathy

Differences in sex development

DiGeorge syndrome (22q11 deletion)

Diphtheria

Discoid eczema

Dislocated kneecap

Dislocated shoulder

Dissociative disorders

Diverticular disease and diverticulitis

Dog bites, see Animal and human bites

Down’s syndrome

Dupuytren’s contracture

DVT (deep vein thrombosis)

Dwarfism, see Restricted growth (dwarfism)

Dysarthria (difficulty speaking)

Dysentery

Dyslexia in adults

Dyslexia in children

Dyspraxia in adults

Dyspraxia in children, see Developmental co-ordination disorder (dyspraxia) in children

Dystonia

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E

Ear infections

Eardrum (burst), see Perforated eardrum

Early or delayed puberty

Early or premature menopause

Earwax build-up

Eating disorders

Ebola virus disease

Ectopic pregnancy

Ectropion

Eczema (atopic), see Atopic eczema

Eczema (contact dermatitis), see Contact dermatitis

Eczema (discoid), see Discoid eczema

Eczema (varicose), see Varicose eczema

Edwards’ syndrome (trisomy 18)

Ehlers-Danlos syndromes

Ejaculation problems

Encephalitis

Endocarditis

Endometrial cancer, see Womb (uterus) cancer

Endometriosis

Enlarged prostate

Epidermolysis bullosa

Epididymitis

Epiglottitis

Epilepsy

Erectile dysfunction (impotence)

Erythema multiforme

Erythema nodosum

Erythrocytosis

Erythromelalgia

Excessive daytime sleepiness (hypersomnia)

Excessive sweating (hyperhidrosis)

Eye cancer

Eye cancer in children, see Retinoblastoma

Eye infection (herpes), see Herpes simplex eye infections

Eye injuries

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F

Fabricated or induced illness

Face blindness, see Prosopagnosia (face blindness)

Falls

Febrile seizures

Female genital mutilation (FGM)

Fetal alcohol spectrum disorder

Fibroids

Fibromyalgia

Fits (children with fever), see Febrile seizures

Flat feet

Flat head syndrome (plagiocephaly and brachycephaly)

Flat head syndrome, see Flat head syndrome (plagiocephaly and brachycephaly)

Flu

Food allergy

Food intolerance

Food poisoning

Foot drop

Foreskin problems, see Tight foreskin (phimosis)

Frontotemporal dementia

Frostbite

Frozen shoulder

Functional neurological disorder, see Medically unexplained symptoms

Fungal nail infection

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G

Gallbladder cancer

Gallbladder pain, see Acute cholecystitis

Gallstones

Ganglion cyst

Gangrene

Gastritis

Gastro-oesophageal reflux disease (GORD), see Heartburn and acid reflux

Gastroparesis

Gender dysphoria and incongruence

Generalised anxiety disorder (GAD)

Genital herpes

Genital warts

German measles, see Rubella (german measles)

Gestational diabetes

Giant cell arteritis, see Temporal arteritis

Giardiasis

Gilbert’s syndrome

Glandular fever

Glaucoma

Glomerulonephritis

Glue ear

Goitre

Gonorrhoea

Gout

Granuloma annulare

Granulomatosis with polyangiitis (GPA)

Group B strep

Growing pains

Guillain-Barré syndrome

Gum disease

Gynaecomastia

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H

Haemochromatosis

Haemolytic disease of the fetus and newborn (HDFN)

Haemophilia

Haemophilus influenzae type b (Hib)

Haemorrhoids, see Piles (haemorrhoids)

Hamstring injury

Hand, foot and mouth disease

Hantavirus

Hay fever

Head injury and concussion

Head lice and nits

Headaches

Headaches (tension-type), see Tension headaches

Health anxiety

Hearing loss

Heart attack

Heart block

Heart disease (coronary), see Coronary heart disease

Heart failure

Heart rhythm problems (arrhythmia)

Heart valve disease

Heartburn and acid reflux

Heat exhaustion and heatstroke

Heat rash (prickly heat)

Heavy periods

Henoch-Schönlein purpura (HSP)

Hepatitis

Hepatitis A

Hepatitis B

Hepatitis C

Hereditary haemorrhagic telangiectasia (HHT)

Hereditary spastic paraplegia

Hernia

Hernia (hiatus), see Hiatus hernia

Hernia (umbilical), see Umbilical hernia

Herpes (genital), see Genital herpes

Herpes in babies, see Neonatal herpes (herpes in a baby)

Herpes simplex eye infections

Herpetic whitlow (whitlow finger)

Hiatus hernia

Hib, see Haemophilus influenzae type b (Hib)

Hidradenitis suppurativa (HS)

High blood pressure

High blood sugar (hyperglycaemia)

High cholesterol

Hip dysplasia, see Developmental dysplasia of the hip

Hirschsprung’s disease

HIV and AIDS

Hives

Hoarding disorder

Hodgkin lymphoma

Hookworm, see Worms in humans

Hughes syndrome, see Antiphospholipid syndrome (APS)

Human bites, see Animal and human bites

Human papillomavirus (HPV)

Huntington’s disease

Hydrocephalus

Hydronephrosis

Hyperacusis, see Noise sensitivity (hyperacusis)

Hyperhidrosis, see Excessive sweating (hyperhidrosis)

Hyperparathyroidism

Hypersomnia, see Excessive daytime sleepiness (hypersomnia)

Hypertension, see High blood pressure

Hyperthyroidism, see Overactive thyroid (hyperthyroidism)

Hypoglycaemia, see Low blood sugar (hypoglycaemia)

Hypoparathyroidism

Hypotension, see Low blood pressure (hypotension)

Hypothermia

Hypothyroidism, see Underactive thyroid (hypothyroidism)

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I

IBD, see Inflammatory bowel disease

Ichthyosis

Idiopathic pulmonary fibrosis

Impetigo

Impotence, see Erectile dysfunction (impotence)

Incontinence (bowel), see Bowel incontinence

Incontinence (urinary), see Urinary incontinence

Indigestion

Infected piercings

Infertility

Inflammatory bowel disease

Influenza, see Flu

Ingrown hairs

Ingrown toenail

Insect bites and stings

Insomnia

Intersex, see Differences in sex development

Interstitial cystitis, see Bladder pain syndrome (BPS)

Intracranial hypertension

Iron deficiency anaemia

Irritable bowel syndrome (IBS)

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J

Japanese encephalitis

Jaundice

Jaundice in babies

Jaw pain, see Temporomandibular disorder (TMD)

Jellyfish and other sea creature stings

Jet lag

Joint hypermobility syndrome

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K

Kawasaki disease

Keloid scars

Keratosis pilaris

Kidney cancer

Kidney failure, see Chronic kidney disease

Kidney infection

Kidney stones

Klinefelter syndrome

Knee cartilage damage, see Meniscus tear (knee cartilage damage)

Knock knees

Knocked-out tooth

Kyphosis

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L

Labial fusion

Labyrinthitis and vestibular neuritis

Lactose intolerance

Lambert-Eaton myasthenic syndrome

Laryngeal cancer

Laryngitis

Lazy eye

Learning disabilities

Leg cramps

Leg ulcer, see Venous leg ulcer

Legionnaires’ disease

Leptospirosis (Weil’s disease)

Leukaemia (acute lymphoblastic), see Acute lymphoblastic leukaemia

Leukaemia (acute myeloid), see Acute myeloid leukaemia

Leukaemia (chronic lymphocytic), see Chronic lymphocytic leukaemia

Leukoplakia

Lichen planus

Lichen sclerosus

Lipoedema

Lipoma

Listeriosis

Liver cancer

Liver disease

Liver disease (alcohol-related), see Alcohol-related liver disease

Long COVID

Long QT syndrome

Long-sightedness

Low blood pressure (hypotension)

Low blood sugar (hypoglycaemia)

Low sperm count

Low white blood cell count

Low-grade brain tumours, see Non-cancerous (benign) brain tumours

Lung cancer

Lupus

Lyme disease

Lymphoedema

Lymphoma (Hodgkin), see Hodgkin lymphoma

Lymphoma (non-Hodgkin, see Non-Hodgkin lymphoma

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M

Macular degeneration (age-related), see Age-related macular degeneration (AMD)

Macular hole

Malaria

Male menopause, see The ‘male menopause’

Malignant brain tumour (brain cancer)

Mallet finger

Malnutrition

Marfan syndrome

Mastitis

Mastocytosis

Mastoiditis

Measles

Medically unexplained symptoms

Melanoma skin cancer

Meningitis

Meniscus tear (knee cartilage damage)

Menopause (early), see Early or premature menopause

Menopause and perimenopause

Mesothelioma

Metabolic syndrome

Middle East respiratory syndrome (MERS)

Migraine

Miscarriage

Molar pregnancy

Moles

Molluscum contagiosum

Morton’s neuroma

Motion sickness

Motor neurone disease (MND)

Mouth cancer

Mouth thrush, see Oral thrush (mouth thrush)

Mouth ulcers

Mpox

MRSA

Mucositis

Multiple sclerosis

Multiple system atrophy (MSA)

Mumps

Munchausen syndrome

Muscular dystrophy

Myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS)

Myasthenia gravis

Myelodysplastic syndrome (MDS)

Myeloma

Myopia, see Short-sightedness (myopia)

Myositis

Ménière’s disease

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N

Nail fungal infection, see Fungal nail infection

Nappy rash

Narcolepsy

Nasal and sinus cancer

Nasal polyps

Nasopharyngeal cancer

Necrotising fasciitis

Neonatal herpes (herpes in a baby)

Nephrotic syndrome in children

Neurofibromatosis type 1 (NF1)

Neurofibromatosis type 2 (NF2)

Neuromyelitis optica (NMO)

Newborn jaundice, see Jaundice in babies

Newborn respiratory distress syndrome

Night terrors and nightmares

Noise sensitivity (hyperacusis)

Non-alcoholic fatty liver disease (NAFLD)

Non-allergic rhinitis

Non-cancerous (benign) brain tumours

Non-Hodgkin lymphoma

Non-melanoma skin cancer

Noonan syndrome

Norovirus (vomiting bug)

Nosebleed

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O

Obesity, see Overweight and obesity in adults

Obsessive compulsive disorder (OCD)

Oesophageal atresia and tracheo-oesophageal fistula

Oesophageal cancer

Oral thrush (mouth thrush)

Orf

Osteoarthritis

Osteomalacia, see Rickets and osteomalacia

Osteomyelitis

Osteophyte (bone spur)

Osteoporosis

Otosclerosis

Ovarian cancer

Ovarian cyst

Overactive thyroid (hyperthyroidism)

Overweight and obesity in adults

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P

Paget’s disease of bone

Paget’s disease of the nipple

Pancreatic cancer

Pancreatitis (chronic), see Chronic pancreatitis

Panic disorder

Parkinson’s disease

Patau’s syndrome

Pelvic inflammatory disease

Pelvic organ prolapse

Pemphigus vulgaris

Penile cancer

Peptic ulcer, see Stomach ulcer

Perforated eardrum

Pericarditis

Perinatal anxiety, see Anxiety in pregnancy

Periods

Periods (heavy), see Heavy periods

Peripheral arterial disease (PAD)

Peripheral neuropathy

Peritonitis

Personality disorders

Peyronie’s disease

Phaeochromocytoma

Phimosis, see Tight foreskin (phimosis)

Phlebitis (superficial thrombophlebitis)

Phobias

Piles (haemorrhoids)

Pilonidal sinus

PIP breast implants

Pityriasis rosea

Pityriasis versicolor

Plantar fasciitis

Pleurisy

PMS (premenstrual syndrome)

Pneumonia

Poisoning

Polio

Polycystic kidney disease (autosomal dominant), see Autosomal dominant polycystic kidney disease

Polycystic kidney disease (autosomal recessive), see Autosomal recessive polycystic kidney disease

Polycystic ovary syndrome

Polyhydramnios (too much amniotic fluid)

Polymorphic light eruption

Polymyalgia rheumatica

Pompholyx (dyshidrotic eczema)

Post-herpetic neuralgia

Postnatal depression

Postpartum psychosis

Postural tachycardia syndrome (PoTS)

Prader-Willi syndrome

Pre-eclampsia

Pregnancy

Premature ejaculation, see Ejaculation problems

Pressure ulcers (pressure sores)

Prickly heat, see Heat rash (prickly heat)

Primary biliary cholangitis (primary biliary cirrhosis)

Problems swallowing pills

Progressive supranuclear palsy

Prosopagnosia (face blindness)

Prostate cancer

Prostate enlargement, see Enlarged prostate

Prostatitis

Psoriasis

Psoriatic arthritis

Psychosis

Psychotic depression

PTSD (post-traumatic stress disorder)

Puberty (early or delayed), see Early or delayed puberty

Pubic lice

Pudendal neuralgia

Pulmonary embolism

Pulmonary fibrosis, see Idiopathic pulmonary fibrosis

Pulmonary hypertension

Pyoderma gangrenosum

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Q

Q fever

Quinsy, see Tonsillitis

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R

Rabies

Raynaud’s

Reactive arthritis

Rectal cancer, see Bowel cancer

Reflux in babies

Renal cancer, see Kidney cancer

Repetitive strain injury (RSI)

Respiratory syncytial virus (RSV)

Respiratory tract infections (RTIs)

Restless legs syndrome

Restricted growth (dwarfism)

Retinal detachment, see Detached retina (retinal detachment)

Retinal migraine

Retinoblastoma

Rett syndrome

Reye’s syndrome

Rhesus disease, see Haemolytic disease of the fetus and newborn (HDFN)

Rheumatic fever

Rheumatoid arthritis

Rhinitis (allergic), see Allergic rhinitis

Rickets and osteomalacia

Ringworm

Rosacea

Roseola

Roundworm, see Worms in humans

RSV, see Respiratory syncytial virus (RSV)

Rubella (german measles)

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S

Salivary gland stones

Sarcoidosis

Scabies

Scarlet fever

Scars

Schistosomiasis (bilharzia)

Schizophrenia

Sciatica

Scleroderma

Scoliosis

Scurvy

Seasonal affective disorder (SAD)

Seizures (children with fever), see Febrile seizures

Selective mutism

Self-harm

Sepsis

Septic arthritis

Septic shock, see Sepsis

Sexually transmitted infections (STIs)

Shin splints

Shingles

Short-sightedness (myopia)

Shoulder impingement

Sick building syndrome

Sickle cell disease

Silicosis

Sinusitis (sinus infection)

Sjögren’s syndrome

Skin abscess

Skin cancer (melanoma), see Melanoma skin cancer

Skin cancer (non-melanoma), see Non-melanoma skin cancer

Skin cyst

Skin picking disorder

Skin tags

Slapped cheek syndrome

Sleep apnoea

Sleep paralysis

Sleepiness, see Excessive daytime sleepiness (hypersomnia)

Sleepwalking

Slipped disc

Snake bites

Social anxiety (social phobia)

Soft tissue sarcoma

Solar keratoses, see Actinic keratoses (solar keratoses)

Sperm count (low), see Low sperm count

Spina bifida

Spinal muscular atrophy (SMA)

Spondylolisthesis

Sprains and strains

Squint

Stammering

Staph infection

Steroid misuse, see Anabolic steroid misuse

Stevens-Johnson syndrome

Stillbirth

Sting or bite (insect), see Insect bites and stings

Stomach cancer

Stomach ulcer

Strep A

Stretch marks

Stroke

Stuttering, see Stammering

Stye

Subarachnoid haemorrhage

Subdural haematoma

Sunburn

Superficial thrombophlebitis, see Phlebitis (superficial thrombophlebitis)

Supraventricular tachycardia (SVT)

Swallowing pills, see Problems swallowing pills

Sweat rash, see Heat rash (prickly heat)

Sweating (excessive), see Excessive sweating (hyperhidrosis)

Swollen ankles, feet and legs (oedema)

Swollen arms and hands (oedema)

Syphilis

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T

Tailbone (coccyx) pain

Tapeworm, see Worms in humans

TB, see Tuberculosis (TB)

Temporal arteritis

Temporomandibular disorder (TMD)

Tendonitis

Tennis elbow

Tension headaches

Testicular cancer

Tetanus

Thalassaemia

The ‘male menopause’

Thoracic outlet syndrome

Threadworms

Thrombophilia

Thrush in men and women

Thyroid (overactive), see Overactive thyroid (hyperthyroidism)

Thyroid (underactive), see Underactive thyroid (hypothyroidism)

Thyroid cancer

TIA, see Transient ischaemic attack (TIA)

Tick-borne encephalitis (TBE)

Tics

Tight foreskin (phimosis)

Tinnitus

Toe pain

Tongue-tie

Tonsillitis

Tooth (chipped or broken), see Chipped, broken or cracked tooth

Tooth decay

Tooth knocked out, see Knocked-out tooth

Tourette syndrome

Toxic shock syndrome

Toxocariasis

Toxoplasmosis

Transient ischaemic attack (TIA)

Trichomoniasis

Trichotillomania (hair pulling disorder)

Trigeminal neuralgia

Trigger finger

Tuberculosis (TB)

Turner syndrome

Type 1 diabetes

Type 2 diabetes

Typhoid fever

Typhus

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U

Ulcerative colitis

Umbilical hernia

Underactive thyroid (hypothyroidism)

Undescended testicles

Urethritis

Urinary incontinence

Urinary tract infections (UTIs)

Uterine (womb) cancer, see Womb (uterus) cancer

Uveitis

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V

Vaginal cancer

Vaginal pain, see Vulvodynia (vulval pain)

Vaginismus

Vaginitis

Varicose eczema

Varicose veins

Vascular dementia

Vasculitis

Venous leg ulcer

Verrucas, see Warts and verrucas

Vertigo

Vestibular neuritis, see Labyrinthitis and vestibular neuritis

Vision loss

Vitamin B12 or folate deficiency anaemia

Vitiligo

Vomiting bug, see Norovirus (vomiting bug)

Von Willebrand disease

Vulval cancer

Vulvodynia (vulval pain)

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W

Warts and verrucas

Weil’s disease, see Leptospirosis (Weil’s disease)

Whiplash

White blood cell count (low), see Low white blood cell count

Whitlow finger, see Herpetic whitlow (whitlow finger)

Whooping cough

Wolff-Parkinson-White syndrome

Womb (uterus) cancer

Women’s health

Worms in humans

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X

There are currently no conditions listed

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Y

Yellow fever

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Z

Zika virus